雄性禿掉髮跟前列腺癌有關嗎? @董哥的家 iwanthair's blog

雄性禿與攝護腺癌都是與DHT有所相關，那雄性禿掉髮比較有可能，或比較不可能得到攝護腺癌?
雄性禿掉髮跟前列腺癌有關嗎? @董哥的家 iwanthair's blog

一項有938個男性受試者的研究回答了這個問題，而結果可能會令人感到驚訝！這對雄性禿的男士來說，也能算是一個好消息了！

雄性禿男性不只要應付將來可能發生的掉髮，也必須應付潛在的健康問題，因為有許多的研究發現掉髮與心臟疾病間的關聯。但最近發表的一個研究中，比較了938位男性的掉髮模式、開始禿髮的年齡、和一些其它的變數來找出這其中的關聯。他們不只發現禿頭與心臟病無關，還發現在較年輕的時候禿頭比較不容易患有前列腺癌。請看以下的研究

對患有前列腺癌的高風險男性來說，雄性禿不是一個有效的指標

Eur J Cancer. 2010 Jun 17
Cremers RG, Aben KK, Vermeulen SH, den Heijer M, van Oort IM, Kiemeney LA.
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands.

背景：男性賀爾蒙在攝護腺癌(PC)與雄性禿(AA)的病原生理學中扮演一個主要的角色。兩種表現型間的關聯與患有PC的高風險男性有關。我們在一個病例對照實驗中評估各個年紀的AA與PC間的關聯。

方法：938個從人口為罹患攝護腺癌症族群裡取得的病患做為病例組(實驗組)。控制組(n=2160)是從一般男性中的隨機取樣。所有的受試者都完成癌症風險因子的問卷調查，其中包括使用改編自Hamilton-Norwood 量表(雄性禿七個分期)中關於頭髮在不同年齡時的外觀、種族與攝護腺癌的家族史的問題。使用多變項羅吉斯回歸分析比值比(ORs)和95%信賴區間。

結果：早年時禿髮顯示與患攝護腺癌較低風險有關(20歲時禿髮：OR=0.86; 95% CI 0.69-1.07 與40歲時禿髮 OR=0.81; 95% CI 0.70-0.96)。完成問卷時顯示，有雄性禿與患有攝護腺癌無關(OR=1.10; 95% CI 0.89-1.34.)。單獨就”前額禿”或”頂禿”來說，在任何年齡時禿髮都與患有攝護腺癌無顯著相關。40歲時同時有”前額禿”與”頂禿”與降低患有攝護腺癌風險有關(OR=0.62; 95% CI 0.45-0.86)。雄性禿與侵入性攝護腺癌之間沒有關聯。

結論：我們並沒有發現各個年齡時患有雄性禿與攝護腺癌間有一致性的正相關。令人驚訝地是，如果要說其中有甚麼關係的話，這個研究指出，較年輕的時候得到雄性禿與患有攝護腺癌是呈負相關。因此，雄性禿對於將來患有攝護腺癌的高風險男性來說並不是一項有效的指標。

By iwanthair’s blog & Jinny

Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer.

BACKGROUND: Androgens are assumed to play a central role in the pathophysiology of both prostate cancer (PC) and androgenic alopecia (AA). A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages and PC in a large case-control study.

METHODS: The case group comprised 938 PC patients recruited from a population-based cancer registry. The controls (n=2160) were a random sample of the male general population. All subjects completed a questionnaire on risk factors for cancer, including questions on hair pattern at different ages using an adapted version of the Hamilton-Norwood scale, race and family history of PC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression.

RESULTS: Baldness at early age appeared to be associated with a lower risk of PC (baldness at age 20: OR=0.86; 95% CI 0.69-1.07 and baldness at age 40: OR=0.81; 95% CI 0.70-0.96). Baldness at completion of the questionnaire was not associated with PC: OR=1.10; 95% CI 0.89-1.34. An isolated ‘frontal baldness’ or ‘vertex baldness’ pattern was not significantly associated with PC at any age. Presence of a combined ‘frontal and vertex’ baldness pattern at age 40 was associated with a decreased risk of PC (OR=0.62; 95% CI 0.45-0.86). There were no significant associations between AA and aggressive PC.

CONCLUSIONS: We did not find consistent positive associations between AA at different ages and PC. Surprisingly, if anything, baldness at early age is inversely related to PC in this study. Androgenic alopecia is not useful as an indicator of men at high risk of PC. Copyright © 2010 Elsevier Ltd. All rights reserved.

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