有時會因為忙碌而忘記每天服用一次柔沛或是波斯卡,
甚至於吃了之後還會得了失憶症,忘了自己到底今天吃了沒?
試想,有沒有可能柔沛可以方便到一個月只吃一次,藥效就可以持續?
根據最近在中國長沙中南大學進行的一個研究顯示,長效型的Finasteride 1mg 在未來是可能的達到的。
這種長效型柔沛的的創意是希望藉由將成分包裹在藥中,隨著時間而逐漸發揮藥效,就可以免除每天服用一次的不便。在這個研究中,Finasteride被包裹在propylene carbonate maleate (PPCM)的膠囊中,實驗結果顯示,藥效會在5~6週的時間逐漸釋放。雖然這只是初步的實驗,但因為已有其他長效型藥物的成功案例,所以長效型的Finasteride,在未來還是可以預期的喔!
不過我在想,這長效型柔沛雖然方便,但一顆要多少錢?
如果吃一星期就有副作用產生,該怎麼辦? 留給科學家去傷腦筋吧!
By iwanthair’s blog
資料出處:
Preparation of novel polymeric microspheres for controlled release of finasteride.
Int J Pharm. 2007 May 13. Peng D, Huang K, Liu Y, Liu S.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
The utility of the novel polycarbonate, poly(propylene carbonate maleate) (PPCM) to encapsulate and control the release of finasteride, via microspheres, was investigated. The PPCM microspheres loaded with finasteride were elaborated by a simple oil-in-water (O/W) emulsion-solvent evaporation method. Various manufacturing parameters, including the concentration of polymer in dichloromethane (DCM) and the polymer:finasteride ratios were altered to optimize process variables during the microspheres production. The effects of these changes on the characteristics of the microspheres were examined. The structure and morphology were characterized by wide-angle X-ray diffraction (WXRD) and scanning electron microscopy (SEM). The results showed that the mean diameter of microspheres was approximately 2mum, and had both smooth and spherical surfaces. Greater encapsulation efficiency was obtained by increasing the ratios of polymer:finasteride and the concentration of PPCM in DCM. In vitro drug release of these microcapsules was performed in a pH 7.4 phosphate-buffered solution. The release profiles of finasteride from PPCM microcapsules were found to be biphasic with a burst release followed by a gradual release phase. A prolonged in vitro drug release profile was observed. After an initial burst, a continuous drug release was observed for up to 5-6 weeks.
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你好
想請問您一個問題
就是如果吃柔沛的話
是不是男性荷爾蒙就會減少呢?
也就是比較不會長鬍子(這樣其實也還不錯)
還是說Finasteride的作用只是會抑制5a還原酶
以及產生某些普遍提到的副作用
謝謝
版主回覆:(05/18/2010 03:19:45 PM)
Finasteride的作用還是以抑制5a還原酶為主的,並非去抑制雄性荷爾蒙的分泌的(但實際上仍有影響),
而且雄性激素是我們身體所必須,是不可以任意減少的阿~
在原廠的說明書中是這樣寫的:
『對雄性禿患者投予Finasteride可降低其頭皮及血清中DHT濃度,
這些降低現象與Finasteride的療效關係尚未確立。對先天易罹患雄性激素造成禿頭的人,
Finasteride似乎可藉此機制阻斷形成雄性激素造成的禿頭的關鍵因子』
請問董哥
如果柔沛等藥物只是單純抑制5阿法
為何還會有許多人感到性欲下降或硬度不如以往
照理說抑制5阿法應該不會這樣吧
誘惑者其實有抑制到部份雄性荷爾蒙
會有副作用應該是荷爾蒙的關係不是嗎
版主回覆:(05/18/2010 03:20:31 PM)
問的好!! 柔沛等藥物”不是”抑制荷爾蒙的分泌,但過程中,若要在很詳細的檢視,還是有少數個案有副作用產品,所以其實多少會有抑制到雄性荷爾蒙的(DHT也是雄性荷爾蒙)。 但,我們卻不知道,為何少數人會受影響,抑或其實每個人都會收到影響,只是程度的不同呢??
您可能看到我上述的回答,所以我一併修改一下~^^ 謝謝