Trinov是義大利最新的抗脫髮產品，主要是針對雄性禿，經過多年的研發，已經在2018年12月於義大利上市，美國預計於2019年上市。Trinov將為男性和女性開發，該產品已完成Fidia的所有安全性和有效性測試，產品型態有乳液、洗髮精、口服營養補充品。洗髮精跟口服產品之後才會上市。
官網：https://www.trinovanticaduta.com/it
電子書download：https://www.fidiapharma.com/all/Trinov_Comunicato_Stampa_2018.pdf
使用六個月的效果：
產品簡介：
Trinov歸類為化妝品，它是由Dr. Giovanni Brotzu和他的研究團隊所研發。研究持續了六年左右，最近發表在科學雜誌“皮膚病治療”上，強調此為技術創新的改善脫髮方式，主要是針對雄性禿脫髮。Trinov有兩個版本，一個專門針對女性。Trinov採用微脂體傳導（如同Revivogen）的特性、乳液型態能將有效成分運送到頭皮。
幾個主要的有效成分：
Dihomo-γ-linolenic acid（DGLA），可改善微循環，讓血液和營養物質流向毛囊。
來自大豆的S-Equolo異黃酮能，抑制5α-還原酶的活性。這減少了睾酮向二氫睾酮（DHT）的轉化。
丙酰-L-肉鹼，促進脂質代謝，刺激能量產生，保護組織免受氧化損傷。
PGE1，刺激角蛋白的產生。
Trinov乳液六個月的臨床實驗結果：
測試方法
所有參與者，呈現了典型的雄性禿脫髮。分成兩組，男性在18至55歲之間，女性在30至60歲之間。每天使用1毫升Trinov乳液為期六個月。然後以第1、3、6個月的測量結果，在頭髮總數、拉伸強度、和洗髮後的掉髮數量做紀錄。此外，參與測試的皮膚科醫生被要求評估是否有任何癢，灼熱或頭皮屑等副作用。
結果
根據所分析的參數，受試者的主觀判斷令人滿意：87％的男性和76％的女性確認Trinov符合他們的期望。確認也由實驗室數據確認。事實上，從治療開始的六個月後，生長期的頭髮男性增加5％，女性增加10.3％。 關於洗滌試驗，該研究測得男性掉髮量減少37.9％，女性掉髮量減少33.4％。
Giovanni Brotzu博士的2018年研究：
Dermatol Ther. 2018 Oct 29:e12778. doi: 10.1111/dth.12778.
A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation.
Brotzu , Fadda , Manca , Manca , Marongiu , Campisi , Consolaro
Abstract
Hair loss is a common aesthetic disorder that can be triggered by genetic, inflammatory, hormonal, and environmental factors acting on hair follicles and their life cycle. There are several types of hair loss that differ in causes, symptoms, and spatial and temporal progression. Androgenic alopecia, a common form of hair loss, is the consequence of a decreased microcirculation of the scalp as well as the toxic action of elevated dihydrotestosterone levels on the hair bulbs. In the present study, the lotions TRINOV Lozione Anticaduta Uomo and TRINOVLozione Anticaduta Donna, containing dihomo-γ-linolenic acid (DGLA), S-equol, and propionyl-l-carnitine, were tested on 30 men and 30 women (mean age of men was 46.6 ± 6.4 years; mean age of women was 49.5 ± 9.0) with signs of androgenic alopecia, respectively. DGLA is a precursor of the prostaglandin PGE1, which acts by improving microcirculation; S-equol inhibits 5α-reductases, thus preventing the transformation of testosterone into dihydrotestosterone; and propionyl-l-carnitine promotes lipid metabolism, stimulating energy production. These three molecules are loaded into liposomes for their effective transdermal delivery. Daily topical applications of the lotions resulted in a hair count that significantly increased for women and marginally increased for men after 6 months of treatment. Furthermore, significant increase in anagen hair and a significant decrease in telogen hair were observed starting from 3 months in male and 1 month in female patients. Thus, the formulations under investigation were effective in attenuating androgenic alopecia-related hair loss in men and women. © 2018 Wiley Periodicals, Inc.
30名男性，30名女性接受試驗。男性3個月和女性患者1個月開始，觀察到毛髮生長期毛髮的顯著增加和休止期頭髮顯著減少。因此，所研究的製劑可有效減輕男性和女性中雄激素性脫髮相關的脫髮。
Trinov電子書的摘要：
After six months of daily application of TRINOV men’s anti-fall lotion the increase of total number of hair is observed in 63% of subjects treated; more than 70% perceive a minor fall, improve the condition of the scalp and report feeling healthier and stronger hair.
After 6 months of daily application of TRINOV Women Fallout Lotion the increase in the number total hair is observed in 90% of subjects treated; more than 70% report an improvement in the state of the scalp and refers to feel healthier and stronger hair, and almost 70% perceives one lower fall.
每天使用TRINOV男士抗脫髮乳液六個月後，63％的受治療者觀察到頭髮總數增加; 超過70％的人認為掉髮量減少，改善頭皮狀況，並報告感覺更健康，更強壯的頭髮。
在每日使用TRINOV女性防輻射乳液6個月後，在90％的受治療者中觀察到總毛髮數量的增加; 超過70％的人表示頭皮狀況有所改善，並且感覺頭髮更健康，更強壯，近70％的人認為掉髮減少。
此產品值得嘗試嗎？
目前可以找到的非藥性產品中，有臨床實驗的產品是少之又少，此產品的臨床實驗受試者雖然不是很多，但受試者的回饋還算是很面的，所以還是值得嘗試。不過也需要提醒大家，已經萎縮的毛囊仍然不可能受惠於此產品。價格上，剛上市的售價還是高了一些，希望日後能夠再往下調整。
產品規格：
每瓶30ml，每天使用一次，一瓶一個月的份量.
義大利價格約69歐元左右（約合台幣2440）.
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