胸腺胜肽應用的新研究

《Journal of Plastic Dermatology》近期發佈的一項全新研究再次確認，胸腺胜肽對治療脫髮具有效果。休止期脫髮 (TE) 和雄性禿脫髮 (AGA) 是導致脫髮的兩個主要原因。目前的研究表明，合成型胸腺胜肽經證實對AGA和慢性TE均具有臨床效果。

研究設計與結果
該調查的目標是檢驗低分子量胸腺胜肽（GKL factor）在為期6個月中對第一階段 AGA 和 TE 的療效與美容程度，採用的是胸腺胜肽與其洗髮精。這項研究在364名慢性 TE 和第一階段 AGA 男女病人中進行。

總結
這項研究所調查的產品取得了良好的臨床效果，即可減緩脫髮並促進增長。在對364名全部參與拉拔測試的病人中，。男性脫髮改善為89％，而女性為95％。該治療還對紅疹、瘙癢和皮脂溢等經常伴隨的典型症狀具有改善的療效。此研究結果也支持之前進行的實驗成果。

重要補充提醒
此研究採用的是脫髮初期的受試者。
研究採用拉扯試驗來評估結果。
治療脫髮，一定要早期且正確治療，沒有什麼比這個更重要的!
胸線胜肽，仍是我認為針對女性脫髮的非藥物首選

原文摘要
Methods:
The treatment schedule was as follows:
– serum: once a day application for a total period of treatment of 24 weeks; (GKL一天一次，為期24周)
– shampoo: three times/week during the study period of 24 weeks.(洗髮精一周三次，為期24周)

All the subjects underwent pull test, evaluation of symptoms (seborrhea, erythema and pruritus).Tolerability and cosmetic acceptance/tolerance were evaluated after 180 days of treatment.

Results:
Men: In AGA patients the improvement of pull test has been of 94% with a mean symptoms improvement of 89%; In TE patients the improvement of pull test has been of 98% with a mean symptoms improvement of 77%. 

Women: In AGA patients the improvement of pull test has been of 98% with a mean symptoms improvement of 95%; In TE patients the improvement of pull test has been of 99% with a mean symptoms improvement of 95%.

In all groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 98% of the cases.

Conclusion:
In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in men and women after a six month-treatment.

資料來源
– Barbareschi M, Arena N et al.: Multicentric study of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic alopecia and chronic telogen effluvium in women and men. Journal of Plastic Dermatology. 2013: Vol.9 (2),

[1] N. Meier: Thymic Peptides Differentially Modulate Human Hair Follicle Growth. Journal of Investigative Dermatology (2012)

[2] Donne Dermatologhe Italia (DDI). Clinical Investigation of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic and chronic telogen effluvium in women. J Plastic Dermatol 2008; 4:199-205

By iwanthair’s blog

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